Rosenblum Lab Molecular and Cellular Mechanisms Underlying Learning and Memory



    Publications in the past 10 years


    PKR: A Kinase to Remember (2019). Gal-Ben-Ari S, Barrera I, Ehrlich M, and Rosenblum K. Frontiers in Molecular Neuroscience. 11:480. doi: 10.3389/fnmol.2018.00480.



    Acquired taste valence encoding in cortico-amygdala circuits (2018). Lavi K, Jacobson GA, Rosenblum K, Lüthi A. Cell Reports. 24(2):278-283. doi: 10.1016/j.celrep.2018.06.053.

    Calcium-Calmodulin-Dependent Kinase II and Eukaryotic Elongation Factor-2 Kinase Pathways Mediate the Antidepressant Action of Ketamine (2018). Adaikkan C, Taha E, Barrera I, David O, Rosenblum K. Biol Psych. pii: S0006-3223(17)32247-3. doi: 10.1016/j.biopsych.2017.11.028.



    Local Inhibition of PERK Enhances Memory and Reverses Age-Related Deterioration of Cognitive and Neuronal Properties (2017). Sharma V, Ounallah-Saad H, Chakraborty D, Hleihil M, Sood R, Barrera I, Edry E, Kolatt Chandran S, Tabou de Leon SB, Kaphzan H, Rosenblum K. J Neurosci. pii: 0628-17. doi: 10.1523/JNEUROSCI.0628-17.2017.

    The Insula and Taste Learning (2017). Yiannakas A, Rosenblum K. Front Mol Neurosci. 10:335. doi: 10.3389/fnmol.2017.00335. eCollection 2017. Review.



    mAChR-dependent decrease in proteasome activity in the gustatory cortex is necessary for novel taste learning (2016). Rosenberg T, Elkobi A, Rosenblum K. Neurobiol Learn Mem. 135:115-124. doi: 10.1016/j.nlm.2016.07.029. Epub 2016 Jul 29.

    Concurrence of High Fat Diet and APOE Gene Induces Allele Specific Metabolic and Mental Stress Changes in a Mouse Model of Alzheimer's Disease (2016). Segev Y, Livne A, Mints M, Rosenblum K. Front Behav Neurosci. 10:170. doi: 10.3389/fnbeh.2016.00170. eCollection 2016.

    eEF2K/eEF2 pathway controls the excitation/inhibition balance and susceptibility to epileptic seizures (2016). Heise C, Taha E, Murru L, Ponzoni L, Cattaneo A, Guarnieri FC, Montani C, Mossa A, Vezzoli E, Ippolito G, Zapata J, Barrera I, Ryazanov AG, Cook J, Poe M, Stephen M, Kopanitsa M, Benfante R, Rusconi F, Braida D, Francolini M, Proud CG, Valtorta F, Passafaro M, Sala M, Bachi A, Verpelli C, Rosenblum K and Sala C. Cereb Cortex. 27(3):2226-2248. doi: 10.1093/cercor/bhw075.

    The differential role of cortical protein synthesis in taste memory formation and persistence (2016). Levitan D, Gal-Ben-Ari S, Heise C, Rosenberg T, Elkobi A, Inberg S, Sala C, Rosenblum K. npj Science of Learning 1: 16001.

    Fluid consumption and taste novelty determines transcription temporal dynamics in the gustatory cortex (2016). Inberg S, Jacob E, Elkobi A, Edry E, Rappaport A, Simpson TI, Armstrong JD, Shomron N, Pasmanik-Chor M, Rosenblum K. Mol Brain 9: 13-016-0188-4.

    NMDAR-dependent proteasome activity in the gustatory cortex is necessary for conditioned taste aversion (2016). Rosenberg T, Elkobi A, Dieterich DC, Rosenblum K. Neurobiol Learn Mem 130: 7-16.



    Expression of Quinone Reductase-2 in the Cortex Is a Muscarinic Acetylcholine Receptor-Dependent Memory Consolidation Constraint (2015). Rappaport AN, Jacob E, Sharma V, Inberg S, Elkobi A, Ounallah-Saad H, Pasmanik-Chor M, Edry E, Rosenblum K. J Neurosci 35: 15568-15581.

    A molecular mechanism underlying gustatory memory trace for an association in the insular cortex (2015). Adaikkan C, Rosenblum K. Elife 4: 10.7554/eLife.07582.

    PKR Inhibition Rescues Memory Deficit and ATF4 Overexpression in ApoE epsilon4 Human Replacement Mice (2015). Segev Y, Barrera I, Ounallah-Saad H, Wibrand K, Sporild I, Livne A, Rosenberg T, David O, Mints M, Bramham CR, Rosenblum K. J Neurosci 35: 12986-12993.

    see commentary: Integrated Stress Response: Connecting ApoE4 to Memory Impairment in Alzheimer’s Disease. Oliveira MM and Lourenco MV. Review of Segev et al.

    see comment to commentary

    Reduced SNAP-25 increases PSD-95 mobility and impairs spine morphogenesis (2015). Fossati G, Morini R, Corradini I, Antonucci F, Trepte P, Edry E, Sharma V, Papale A, Pozzi D, Defilippi P, Meier JC, Brambilla R, Turco E, Rosenblum K, Wanker EE, Ziv NE, Menna E, Matteoli M. Cell Death Differ 22: 1425-1436.



    Differential contribution of hippocampal subfields to components of associative taste learning (2014). Chinnakkaruppan A, Wintzer ME, McHugh TJ, Rosenblum K. J Neurosci 34: 11007-11015.

    Dopamine-induced tyrosine phosphorylation of NR2B (Tyr1472) is essential for ERK1/2 activation and processing of novel taste information (2014). David O, Barrera I, Chinnakkaruppan A, Kaphzan H, Nakazawa T, Yamamoto T, Rosenblum K. Front Mol Neurosci 7: 66.

    Genetic or pharmacological reduction of PERK enhances cortical-dependent taste learning (2014). Ounallah-Saad H, Sharma V, Edry E, Rosenblum K. J Neurosci 34: 14624-14632.

    The roles of protein expression in synaptic plasticity and memory consolidation (2014). Rosenberg T, Gal-Ben-Ari S, Dieterich DC, Kreutz MR, Ziv NE, Gundelfinger ED, Rosenblum K. Front Mol Neurosci 7: 86.



    ApoE epsilon4 is associated with eIF2alpha phosphorylation and impaired learning in young mice (2013). Segev Y, Michaelson DM, Rosenblum K. Neurobiol Aging 34: 863-872.

    Blocking the eIF2alpha Kinase (PKR) Enhances Positive and Negative Forms of Cortex-Dependent Taste Memory (2013). Stern E, Chinnakkaruppan A, David O, Sonenberg N, Rosenblum K. J Neurosci 33: 2517-2525.

    Memory of conditioned taste aversion is erased by inhibition of PI3K in the insular cortex (2013). Slouzkey I, Rosenblum K, Maroun M. Neuropsychopharmacology 38: 1143-1153.

    The role of eEF2 pathway in learning and synaptic plasticity (2013). Taha E, Gildish I, Gal-Ben-Ari S, Rosenblum K. Neurobiol Learn Mem 105: 100-106.

    Taste familiarity is inversely correlated with Arc/Arg3.1 hemispheric lateralization (2013). Inberg S, Elkobi A, Edri E, Rosenblum K. J Neurosci 33: 11734-11743.



    Consolidation and translation regulation (2012). Gal-Ben-Ari S, Kenney JW, Ounalla-Saad H, Taha E, David O, Levitan D, Gildish I, Panja D, Pai B, Wibrand K, Simpson TI, Proud CG, Bramham CR, Armstrong JD, Rosenblum K. Learn Mem 19: 410-422.

    Impaired associative taste learning and abnormal brain activation in kinase-defective eEF2K mice (2012). Gildish I, Manor D, David O, Sharma V, Williams D, Agarwala U, Wang X, Kenney JW, Proud CG, Rosenblum K. Learn Mem 19: 116-125.

    Molecular mechanisms underlying memory consolidation of taste information in the cortex (2012). Gal-Ben-Ari S, Rosenblum K. Front Behav Neurosci 5: 87.

    The role of protein phosphorylation in the gustatory cortex and amygdala during taste learning (2012). Adaikkan C, Rosenblum K. Exp Neurobiol 21: 37-51.



    Rho-associated kinase in the gustatory cortex is involved in conditioned taste aversion memory formation but not in memory retrieval or relearning (2011). Sweetat S, Rosenblum K, Lamprecht R. Neurobiol Learn Mem .

    Virally mediated gene manipulation in the adult CNS (2011). Edry E, Lamprecht R, Wagner S, Rosenblum K. Front Mol Neurosci 4: 57.



    c-Fos expression is elevated in GABAergic interneurons of the gustatory cortex following novel taste learning (2010). Doron G, Rosenblum K. Neurobiol Learn Mem 94: 21-29.

    A novel role for protein synthesis in long-term neuronal plasticity: maintaining reduced postburst afterhyperpolarization (2010). Cohen-Matsliah SI, Motanis H, Rosenblum K, Barkai E. J Neurosci 30: 4338-4342.



    Biphasic activation of the mTOR pathway in the gustatory cortex is correlated with and necessary for taste learning (2009). Belelovsky K, Kaphzan H, Elkobi A, Rosenblum K. J Neurosci 29: 7424-7431.

    CAMKII activation is not required for maintenance of learning-induced enhancement of neuronal excitability (2009). Liraz O, Rosenblum K, Barkai E. PLoS One 4: e4289.

    Identification of novel RasGRF1 interacting partners by large-scale proteomic analysis (2009). Lavagni P, Indrigo M, Colombo G, Martegani E, Rosenblum K, Gnesutta N, Zippel R. J Mol Neurosci 37: 212-224.

    Barki-Harrington, L., Belelovsky, K., Doron, G. & Rosenblum, K. in Conditioned taste aversion: Behavioral and neural processes (eds Reilly, S. & Schachtman, T. R.) 341-363 (Oxford University Press, Oxford, 2009).

    Olfactory-learning abilities are correlated with the rate by which intrinsic neuronal excitability is modulated in the piriform cortex (2009). Cohen-Matsliah SI, Rosenblum K, Barkai E. Eur J Neurosci 30: 1339-1348.

    Tyrosine phosphorylation of the 2B subunit of the NMDA receptor is necessary for taste memory formation (2009). Barki-Harrington L, Elkobi A, Tzabary T, Rosenblum K. J Neurosci 29: 9219-9226.



    Rosenblum, K. in Concise Learning and Memory: The Editor's Selection (ed Byrne, J. H.) 465-479 (Academic Press, Elsevier, Amsterdam, 2008).

    ERK-dependent PSD-95 induction in the gustatory cortex is necessary for taste learning, but not retrieval (2008). Elkobi A, Ehrlich I, Belelovsky K, Barki-Harrington L, Rosenblum K. Nat Neurosci 11: 1149-1151.

    Facilitation of taste memory acquisition by experiencing previous novel taste is protein-synthesis dependent (2008). Merhav M, Rosenblum K. Learn Mem 15: 501-507.

    Juvenile stress-induced alteration of maturation of the GABAA receptor alpha subunit in the rat (2008). Jacobson-Pick S, Elkobi A, Vander S, Rosenblum K, Richter-Levin G. Int J Neuropsychopharmacol 11: 891-903.

    Persistent ERK activation maintains learning-induced long-lasting modulation of synaptic connectivity (2008). Cohen-Matsliah SI, Seroussi Y, Rosenblum K, Barkai E. Learn Mem 15: 756-761.

    Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticity (2008). Antion MD, Merhav M, Hoeffer CA, Reis G, Kozma SC, Thomas G, Schuman EM, Rosenblum K, Klann E. Learn Mem 15: 29-38.



    Behavioral alterations in mice lacking the translation repressor 4E-BP2 (2007). Banko JL, Merhav M, Stern E, Sonenberg N, Rosenblum K, Klann E. Neurobiol Learn Mem 87: 248-256.

    Co-application of NMDA and dopamine-induced rapid translation of RSK2 in the mature hippocampus (2007). Kaphzan H, Doron G, Rosenblum K. J Neurochem 103: 388-399.

    eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory (2007). Costa-Mattioli M, Gobert D, Stern E, Gamache K, Colina R, Cuello C, Sossin W, Kaufman R, Pelletier J, Rosenblum K, Krnjevic K, Lacaille JC, Nader K, Sonenberg N. Cell 129: 195-206.

    Learning-induced modulation of SK channels-mediated effect on synaptic transmission (2007). Brosh I, Rosenblum K, Barkai E. Eur J Neurosci 26: 3253-3260.

    MAPK activation in the hippocampus in vivo is correlated with experimental setting (2007). Belelovsky K, Maroun M, Rosenblum K. Neurobiol Learn Mem 88: 58-64.

    A novel role for extracellular signal-regulated kinase in maintaining long-term memory-relevant excitability changes (2007). Cohen-Matsliah SI, Brosh I, Rosenblum K, Barkai E. J Neurosci 27: 12584-12589.

    A role for eukaryotic translation initiation factor 2B (eIF2B) in taste memory consolidation and in thermal control establishment during the critical period for sensory development (2007). Tirosh S, Elkobi A, Rosenblum K, Meiri N. Dev Neurobiol 67: 728-739.



    Behavioral interference and C/EBPbeta expression in the insular-cortex reveal a prolonged time period for taste memory consolidation (2006). Merhav M, Kuulmann-Vander S, Elkobi A, Jacobson-Pick S, Karni A, Rosenblum K. Learn Mem 13: 571-574.

    Different signal transduction cascades are activated simultaneously in the rat insular cortex and hippocampus following novel taste learning (2006). Yefet K, Merhav M, Kuulmann-Vander S, Elkobi A, Belelovsky K, Jacobson-Pick S, Meiri N, Rosenblum K. Eur J Neurosci 24: 1434-1442.

    Extinction of conditioned taste aversion depends on functional protein synthesis but not on NMDA receptor activation in the ventromedial prefrontal cortex (2006). Akirav I, Khatsrinov V, Vouimba RM, Merhav M, Ferreira G, Rosenblum K, Maroun M. Learn Mem 13: 254-258.

    NMDA and dopamine converge on the NMDA-receptor to induce ERK activation and synaptic depression in mature hippocampus (2006). Kaphzan H, O'Riordan KJ, Mangan KP, Levenson JM, Rosenblum K. PLoS One 1: e138.


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