Rosenblum Lab Molecular and Cellular Mechanisms Underlying Learning and Memory

    In order to measure mRNA translation in live neurons we adopted and modified a cutting edge method developed by Anima Biotech and termed Protein Synthesis Monitoring (PSM). The technology enables viewing global translation using fluorescently labeled tRNAs (Figure 1). Fluorescently labeled tRNA molecules provide insight about the dynamic localization of translation machinery and allow quantitative measurement of protein synthesis in live cells.

    The mammalian brain, even of simple animals, is the most complex biological structure. This highly elaborate organ forms several dimensions of complexity at the different levels of organization, ranging from molecules and cells up to behavior. The cellular properties as well as the molecular apparatus of neurons, subserving individual circuits, operate in the highly branched networks and form the physical and biological basis of cognition.

    We study molecular and cellular mechanisms underlying learning and memory, and recently, depression as well. Since the foundation of the lab, we have been studying the regulation of mRNA translation into protein as a major molecular mechanism underlying learning and memory. Over the years, we have focused on specific molecules that serve as key regulators of protein synthesis, and shown them to be potential targets for memory enhancement in health and disease (e.g., mild dementia, Alzheimer's disease).

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    © 2017 Sagol Department of Neurobiology, University of Haifa | Tel: +972-4-8280015 | Fax: +972-4-8240339 | Email: elkobi.a@gmail.com, Designed by: Shani Zylberman, Computing and Information Systems division