Rosenblum Lab Molecular and Cellular Mechanisms Underlying Learning and Memory

    Publications

      

    Publications in recent years

    2020

    Dopamine-Dependent QR2 Pathway Activation in CA1 Interneurons Enhances Novel Memory Formation. Gould NL, Sharma V, Hleihil M, Kolatt Chandran S, David O, Edry E, Rosenblum K.J Neurosci. 2020 Oct 12:JN-RM-1243-20. doi: 10.1523/JNEUROSCI.1243-20.2020. Online ahead of print. PMID: 33046554

    eIF2α controls memory consolidation via excitatory and somatostatin neurons. Vijendra Sharma , Rapita Sood , Abdessattar Khlaifia , Mohammad Javad Eslamizade , Tzu-Yu Hung , Danning Lou , Azam Asgarihafshejani , Maya Lalzar , Stephen J Kiniry , Matthew P Stokes , Noah Cohen , Alissa J Nelson , Kathryn Abell , Anthony P Possemato , Shunit Gal-Ben-Ari , Vinh T Truong , Peng Wang , Adonis Yiannakas , Fatemeh Saffarzadeh , A Claudio Cuello , Karim Nader , Randal J Kaufman , Mauro Costa-Mattioli , Pavel V Baranov , Albert Quintana , Elisenda Sanz , Arkady Khoutorsky , Jean-Claude Lacaille , Kobi Rosenblum , Nahum Sonenberg .Nature 2020 Oct;586(7829):412-416. doi: 10.1038/s41586-020-2805-8. Epub 2020 Oct 7

    eEF2/eEF2K Pathway in the Mature Dentate Gyrus Determines Neurogenesis Level and Cognition. Elham Taha , Sudarshan Patil , Iliana Barrera , Julia Panov , Mohammad Khamaisy , Christopher G ProudClive R Bramham , Kobi Rosenblum. Curr Biol 2020 Jul 15;S0960-9822(20)30913-1. doi: 10.1016/j.cub.2020.06.061

    D1 Dopamine Receptor Activation Induces Neuronal eEF2 Pathway-Dependent Protein synthesis. Orit David, Iliana Barrera, Nathaniel Gould, Shunit Gal-Ben-Ari and Kobi Rosenblum. Front. Mol. Neurosci.15 May 2020

    Muscarinic-Dependent miR-182 and QR2 Expression Regulation in the Anterior Insula Enables Novel Taste Learning. Gould NL, Elkobi A, Edry E, Daume J, Rosenblum K.eNeuro. 2020 Mar 20. pii: ENEURO.0067-20.2020.

    Measuring mRNA translation in neuronal processes and somata by tRNA-FRET. Koltun B, Ironi S, Gershoni-Emek N, Barrera I, Hleihil M, Nanguneri S, Sasmal R, Agasti SS, Nair D, Rosenblum K. Nucleic Acids Res 6;48(6):e32. 2020 Apr doi:10.1093/nar/gkaa042

    2019

    PKR: A Kinase to Remember. Shunit Gal-Ben-AriIliana Barrera , Marcelo Ehrlich , Kobi Rosenblum Front Mol Neurosci. 2019 Jan 9;11:480.doi: 10.3389/fnmol.2018.00480. eCollection 2019.

    Multi-input Synapses, but Not LTP-Strengthened Synapses, Correlate With Hippocampal Memory Storage in Aged Mice. Wajeeha Aziz  Igor Kraev , Keiko Mizuno , Alastair Kirby , Ton Fang , Huzefa Rupawala , Kamillia Kasbi , Stephanie Rothe , Felix Jozsa , Kobi Rosenblum , Michael G Stewart , K Peter Giese  Curr Biol 2019 Nov 4;29(21):3600-3610.e4. doi: 10.1016/j.cub.2019.08.064. Epub Oct 17,2019.

    Activity of Insula to Basolateral Amygdala Projecting Neurons is Necessary and Sufficient for Taste Valence Representation. Haneen Kayyal, Adonis Yiannakas, Sailendrakumar Kolatt Chandran, Mohammad Khamaisy, Vijendra Sharma, and Kobi Rosenblum. J Neurosci. 2019 Nov20:39(47):9369-9382).

    2018

    Acquired taste valence encoding in cortico-amygdala circuits. Lavi K, Jacobson GA, Rosenblum K, Lüthi A. Cell Reports. 24(2):278-283. doi: 10.1016/j.celrep.2018.06.053, 2018

    Calcium-Calmodulin-Dependent Kinase II and Eukaryotic Elongation Factor-2 Kinase Pathways Mediate the Antidepressant Action of Ketamine. Adaikkan C, Taha E, Barrera I, David O, Rosenblum K. Biol Psych. pii: S0006-3223(17)32247-3. doi: 10.1016/j.biopsych.2017.11.028. 2018

    2017

    Local Inhibition of PERK Enhances Memory and Reverses Age-Related Deterioration of Cognitive and Neuronal Properties. Sharma V, Ounallah-Saad H, Chakraborty D, Hleihil M, Sood R, Barrera I, Edry E, Kolatt Chandran S, Tabou de Leon SB, Kaphzan H, Rosenblum K. J Neurosci. pii: 0628-17. doi: 10.1523/JNEUROSCI.0628-17,2017.

    The Insula and Taste Learning. Yiannakas A, Rosenblum K. Front Mol Neurosci. 10:335. doi: 10.3389/fnmol.2017.00335. eCollection Review, 2017.

    2016

    mAChR-dependent decrease in proteasome activity in the gustatory cortex is necessary for novel taste learning. Rosenberg T, Elkobi A, Rosenblum K. Neurobiol Learn Mem. 135:115-124. doi: 10.1016/j.nlm.2016.07.029. Epub Jul 29, 2016.

    Concurrence of High Fat Diet and APOE Gene Induces Allele Specific Metabolic and Mental Stress Changes in a Mouse Model of Alzheimer's Disease (2016). Segev Y, Livne A, Mints M, Rosenblum K. Front Behav Neurosci. 10:170. doi: 10.3389/fnbeh.2016.00170. eCollection 2016.

    eEF2K/eEF2 pathway controls the excitation/inhibition balance and susceptibility to epileptic seizures. Heise C, Taha E, Murru L, Ponzoni L, Cattaneo A, Guarnieri FC, Montani C, Mossa A, Vezzoli E, Ippolito G, Zapata J, Barrera I, Ryazanov AG, Cook J, Poe M, Stephen M, Kopanitsa M, Benfante R, Rusconi F, Braida D, Francolini M, Proud CG, Valtorta F, Passafaro M, Sala M, Bachi A, Verpelli C, Rosenblum K and Sala C. Cereb Cortex. 27(3):2226-2248. doi: 10.1093/cercor/bhw075, 2016

    The differential role of cortical protein synthesis in taste memory formation and persistence. Levitan D, Gal-Ben-Ari S, Heise C, Rosenberg T, Elkobi A, Inberg S, Sala C, Rosenblum K. npj Science of Learning NPJ Sci 1 6001. Published online 2016 May 11. doi: 10.1038/npjscilearn.2016.

    Fluid consumption and taste novelty determines transcription temporal dynamics in the gustatory cortex. Inberg S, Jacob E., Elkobi A., Edry E., Rappaport A., Simpson TI., Armstrong JD., Shomron N., Pasmanik-Chor M., Rosenblum K. Mol Brain 9: 13-016-0188-4, 2016.

    NMDAR-dependent proteasome activity in the gustatory cortex is necessary for conditioned taste aversion. Rosenberg T., Elkobi A., Dieterich DC., Rosenblum K. Neurobiol Learn Mem 130: 7-16, 2016.

    2015

    Expression of Quinone Reductase-2 in the Cortex Is a Muscarinic Acetylcholine Receptor-Dependent Memory Consolidation Constraint. Rappaport AN, Jacob E, Sharma V, Inberg S, Elkobi A, Ounallah-Saad H, Pasmanik-Chor M, Edry E, Rosenblum K. J Neurosci 35: 15568-15581, 2015.

    A molecular mechanism underlying gustatory memory trace for an association in the insular cortex. Adaikkan C, Rosenblum K. Elife 4: 10.7554/eLife.07582, 2015.

    PKR Inhibition Rescues Memory Deficit and ATF4 Overexpression in ApoE epsilon4 Human Replacement Mice. Segev Y, Barrera I, Ounallah-Saad H, Wibrand K, Sporild I, Livne A, Rosenberg T, David O, Mints M, Bramham CR, Rosenblum K. J Neurosci 35: 12986-12993, 2015.

    Reduced SNAP-25 increases PSD-95 mobility and impairs spine morphogenesis. Fossati G, Morini R, Corradini I, Antonucci F, Trepte P, Edry E, Sharma V, Papale A, Pozzi D, Defilippi P, Meier JC, Brambilla R, Turco E, Rosenblum K, Wanker EE, Ziv NE, Menna E, Matteoli M. Cell Death Differ 22: 1425-1436, 2015.

    2014

    Differential contribution of hippocampal subfields to components of associative taste learning. Chinnakkaruppan A, Wintzer ME, McHugh TJ, Rosenblum K. J Neurosci 34: 11007-11015, 2014.

    Dopamine-induced tyrosine phosphorylation of NR2B (Tyr1472) is essential for ERK1/2 activation and processing of novel taste information. David O, Barrera I, Chinnakkaruppan A, Kaphzan H, Nakazawa T, Yamamoto T, Rosenblum K. Front Mol Neurosci 7: 66, 2014.

    Genetic or pharmacological reduction of PERK enhances cortical-dependent taste learning. Ounallah-Saad H, Sharma V, Edry E, Rosenblum K. J Neurosci 34: 14624-14632, 2014.

    The roles of protein expression in synaptic plasticity and memory consolidation. Rosenberg T, Gal-Ben-Ari S, Dieterich DC, Kreutz MR, Ziv NE, Gundelfinger ED, Rosenblum K. Front Mol Neurosci 7: 86, 2014.

    © 2017 Sagol Department of Neurobiology, University of Haifa | Tel: +972-4-8280015 | Fax: +972-4-8240339 | Email: elkobi.a@gmail.com, Designed by: Shani Zylberman, Computing and Information Systems division