Publications in recent years
2024.
NMDA receptors regulate the firing rate set point of hippocampal circuits without altering single-cell dynamics. Antonella Ruggiero , Leore R Heim , Lee Susman , Dema Hreaky , Ilana Shapira, Maxim Katsenelson , Kobi Rosenblum , Inna Slutsky. Neuron. 2024 Nov 5:S0896-6273(24)00735-9PMID: 39515323 DOI: 10.1016/j.neuron.2024.10.014
2023
mRNA translation in astrocytes controls hippocampal long-term synaptic plasticity and memory. Vijendra Sharma, Mauricio Oliveira, Rapita Sood, Abdessattar Khlaifia, Danning Lou , Mehdi Hooshmandi, Tzu-Yu Hung, Niaz Mahmood, Maya Reeves, David Ho-Tieng, Noah Cohen, Po-chieh Cheng, Mir Munir A. Rahim, Masha Prager-Khoutorsky, Randal J. Kaufman, Kobi Rosenblum , Jean-Claude Lacaille , Arkady Khoutorsky , Eric Klann , and Nahum Sonenberg. November 28, 2023 120 (49) e2308671120 https://doi.org/10.1073/pnas.230867112
Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimer’s disease phenotype in mice. Nathaniel L. Gould, Gila R. Scherer, Silvia Carvalho, Khriesto Shurrush, Haneen Kayyal, Efrat Edry, Alina Elkobi, Orit David, Maria Foqara, Darshit Thakar, Tommaso Pavesi, Vijendra Sharma, Matthew Walker, Matthew Maitland, Orly Dym, Shira Albeck, Yoav Peleg, Nicolas Germain, Ilana Babaev, Haleli Sharir, Maya Lalzar, Boris Shklyar, Neta Hazut, Mohammad Khamaisy, Maxime Lévesque, Gilles Lajoie, Massimo Avoli, Gabriel Amitai, Bruce Lefker, Chakrapani Subramanyam, Brian Shilton, Haim Barr, and Kobi Rosenblum. J Clin Invest. 2023 Aug 10;e162120. doi: 10.1172/JCI162120
Ribosome subunits are upregulated in brain samples of a subgroup of individuals with schizophrenia: A systematic gene expression meta-analysis. Mekiten a, Assif Yitzhaky b, Nathaniel Gould, Kobi Rosenblum, Libi Hertzberg . jpsychires https://doi.org/10.1016/j.jpsychires.2023.06.013
Messenger RNA Translation Defects in Neurodegenerative Diseases. Erik Storkebaum, Ph.D., Kobi Rosenblum, Ph.D., and Nahum Sonenberg, Ph.D. (2023) N Engl J Med 2023; 388:1015-1030
DOI: 10.1056/NEJMra221579
2022
A functional eEF2K-eEF2 pathway in the NAc is critical for the expression of cocaine-induced psychomotor sensitisation and conditioned place preference (2022). Tehila Beiser, Elvira Lisniansky, Moriya Weitz, Alexey Bingor , Etty Grad, Kobi Rosenblum, Claire Thornton, Rami Yaka. Transl Psychiatry 2022 Nov 1;12(1):460. doi: 10.1038/s41398-022-02232-1.
Intrinsic excitability in layer IV-VI anterior insula to basolateral amygdala projection neurons encodes the confidence of taste valence Sailendrakumar Kolatt Chandran, Adonis Yiannakas, Haneen Kayyal, Randa Salalha, Federica Cruciani, Liron Mizrahi, Mohammad Khamaisy, Shani Stern, Kobi Rosenblum (2022). eNeuro 9 December 2022, ENEURO.0302-22.2022; DOI: https://doi.org/10.1523/ENEURO.0302-22.2022
2021
Insular cortex neurons encode and retrieve specific immune responses. Tamar Koren, Re’ee Yifa, Mariam Amer, Maria Krot, Nadia Boshnak , Tamar L. Ben-Shaanan, Hilla Azulay-Debby, Itay Zalayat, Eden Avishai, Haitham Hajjo, Maya Schiller, Hedva Haykin Ben Korin, Dorit Farfara, Fahed Hakim, Oren Kobiler, Kobi Rosenblum, Asya Rolls (2021). Published: November 08, 2021 DOI:https://doi.org/10.1016/j. Cell.2021.10.013
The Role of the Eukaryotic Elongation Factor 2 (eEF2) Pathway in Neuronal Function. Elham Taha and Kobi Rosenblum (2021). The Oxford Handbook of Neuronal Protein Synthesis. Edited by Wayne S. Sossin. Subject: Neuroscience, Molecular and Cellular Systems DOI: 10.1093/oxfordhb/9780190686307.013.4
Somatostatin Interneurons of the Insula Mediate QR2 Dependent Novel Taste Memory Enhancement. Gould NL, Kolatt Chandran S, Kayyal H, Edry E, Rosenblum K (2021). eNeuro. ENEURO0152-21.2021. doi: 10.1523/ENEURO.0152-21.2021. PMID: 34518366
Insula to mPFC reciprocal connectivity differentially underlies novel taste neophobic response and learning in mice. Kayyal H, Chandran SK, Yiannakas A, Gould N, Khamaisy M, Rosenblum K (2021). Elife ;10:e66686. doi:10.7554/eLife.66686.PMID: 34219650
Parvalbumin interneuron inhibition onto anterior insula neurons projecting to the basolateral amygdala drives aversive taste memory retrieval. Yiannakas A, Kolatt Chandran S, Kayyal H, Gould N, Khamaisy M, Rosenblum K (2021).Curr Biol. S0960-9822(21)00523-6. doi:10.1016/j.cub.2021.04.010..PMID: 33930301
4E-BP2–dependent translation in parvalbumin neurons controls epileptic seizure threshold. Vijendra Sharma, Rapita Sood, Danning Lou, Tzu-Yu Hung, Maxime Lévesque, Yelin Han, Jeremy Y. Levett, Peng Wang, Shravan Murthy, Shannon Tansley, Siyan Wang, Nadeem Siddiqui, Soroush Tahmasebi, Kobi Rosenblum, Massimo Avoli, Jean-Claude Lacaille, Nahum Sonenberg, and Arkady Khoutorsky (2021) PNAS 118 (15) e2025522118; https://doi.org/10.1073/pnas.2025522118
2020
Dopamine-Dependent QR2 Pathway Activation in CA1 Interneurons Enhances Novel Memory Formation. Gould NL, Sharma V, Hleihil M, Kolatt Chandran S, David O, Edry E, Rosenblum K (2020). J Neurosci. JN-RM-1243-20. doi: 10.1523/JNEUROSCI.1243-20.2020
eIF2α controls memory consolidation via excitatory and somatostatin neurons. Vijendra Sharma , Rapita Sood , Abdessattar Khlaifia , Mohammad Javad Eslamizade , Tzu-Yu Hung , Danning Lou , Azam Asgarihafshejani , Maya Lalzar , Stephen J Kiniry , Matthew P Stokes , Noah Cohen , Alissa J Nelson , Kathryn Abell , Anthony P Possemato , Shunit Gal-Ben-Ari , Vinh T Truong , Peng Wang , Adonis Yiannakas , Fatemeh Saffarzadeh , A Claudio Cuello , Karim Nader , Randal J Kaufman , Mauro Costa-Mattioli , Pavel V Baranov , Albert Quintana , Elisenda Sanz , Arkady Khoutorsky , Jean-Claude Lacaille , Kobi Rosenblum , Nahum Sonenberg (2021).Nature 586(7829):412-416. doi: 10.1038/s41586-020-2805-8. Epub 2020 Oct 7
eEF2/eEF2K Pathway in the Mature Dentate Gyrus Determines Neurogenesis Level and Cognition. Elham Taha, Sudarshan Patil , Iliana Barrera , Julia Panov , Mohammad Khamaisy , Christopher G Proud, Clive R Bramham , Kobi Rosenblum (2020). Curr Biol S0960-9822(20)30913-1. doi: 10.1016/j.cub.2020.06.061
D1 Dopamine Receptor Activation Induces Neuronal eEF2 Pathway-Dependent Protein synthesis. Orit David, Iliana Barrera, Nathaniel Gould, Shunit Gal-Ben-Ari and Kobi Rosenblum (2020). Front. Mol. Neurosci.15 May 2020.
Muscarinic-Dependent miR-182 and QR2 Expression Regulation in the Anterior Insula Enables Novel Taste Learning. Gould NL, Elkobi A, Edry E, Daume J, Rosenblum K (2020). eNeuro. pii: ENEURO.0067-20.2020.
Measuring mRNA translation in neuronal processes and somata by tRNA-FRET. Koltun B, Ironi S, Gershoni-Emek N, Barrera I, Hleihil M, Nanguneri S, Sasmal R, Agasti SS, Nair D, Rosenblum K (2020). Nucleic Acids Res 6;48(6):e32. 2020 Apr doi:10.1093/nar/gkaa042
2019
PKR: A Kinase to Remember. Shunit Gal-Ben-Ari, Iliana Barrera , Marcelo Ehrlich , Kobi Rosenblum (2020). Front Mol Neurosci. 2019 Jan 9;11:480.doi: 10.3389/fnmol.2018.00480. eCollection 2019.
Multi-input Synapses, but Not LTP-Strengthened Synapses, Correlate With Hippocampal Memory Storage in Aged Mice. Wajeeha Aziz Igor Kraev , Keiko Mizuno , Alastair Kirby , Ton Fang , Huzefa Rupawala , Kamillia Kasbi , Stephanie Rothe , Felix Jozsa , Kobi Rosenblum , Michael G Stewart , K Peter Giese (2019). Curr Biol 2019 Nov 4;29(21):3600-3610.e4. doi: 10.1016/j.cub.2019.08.064.
Activity of Insula to Basolateral Amygdala Projecting Neurons is Necessary and Sufficient for Taste Valence Representation. Haneen Kayyal, Adonis Yiannakas, Sailendrakumar Kolatt Chandran, Mohammad Khamaisy, Vijendra Sharma, and Kobi Rosenblum (2019). J Neurosci. 2019 Nov20:39(47):9369-9382).